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A Quantitative Analysis of the Role of Antihypertensive Drug Dose on Hypertension in Children with Chronic Kidney Disease
(2019)
Hypertension (HTN) is a highly prevalent and major risk factor for poor cardiovascular and kidney outcomes in chronic kidney disease (CKD). Prior research suggests that HTN is underdiagnosed and undertreated in children ...
Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)
Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000
overdose-related emergency room visits annually. A long asymptomatic period and limited
treatment options result in a high rate of liver ...